
BCATc Inhibitor 2
CAS No. 406191-34-2
BCATc Inhibitor 2 ( —— )
产品货号. M27500 CAS No. 406191-34-2
BCATc Inhibitor 2 在 hBCATc 测定中表现出 0.8 microM 的 IC50;它是一种活性和选择性抑制剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥599 | 有现货 |
![]() ![]() |
5MG | ¥988 | 有现货 |
![]() ![]() |
10MG | ¥1596 | 有现货 |
![]() ![]() |
25MG | ¥3345 | 有现货 |
![]() ![]() |
50MG | ¥5006 | 有现货 |
![]() ![]() |
100MG | ¥7120 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称BCATc Inhibitor 2
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述BCATc Inhibitor 2 在 hBCATc 测定中表现出 0.8 microM 的 IC50;它是一种活性和选择性抑制剂。
-
产品描述BCATc Inhibitor 2 exhibited an IC50 of 0.8 microM in the hBCATc assays; it is an active and selective inhibitor. BCATc Inhibitor 2 also blocked calcium influx into neuronal cells following inhibition of glutamate uptake, and demonstrated neuroprotective efficacy in vivo. Branched-chain amino acid transferases (BCATs) have been implicated in catalyzing reversible transamination of isoleucine, leucine, and valine branched-chain amino acids to their corresponding α-keto acids, generating L-glutamate. It has been identified that there are two forms of BCAT in mammals: mitochondrial BCAT (BCATm) and cytosolic BCAT (BCATc). BCATc is expressed in particular brain region and involved in regulating glutamate synthesis for release during neuronal excitation. Thus, BCATc inhibition may be useful for the treatment of neurodegenerative and behavioral disorders involving disturbances of the glutamatergic system.(In Vitro):BCATc inhibition is likely to be useful for the treatment of neurodegenerative and other neurological disorders involving disturbances of the glutamatergic system. In the hBCATc assays, BCATc Inhibitor 2 exhibited an IC50 of 0.8 ± 0.05 μM. In a recombinant rat BCATc assay and a crude rat BCATm assay, the IC50 was 0.2 μM ± 0.02 and 3.0 μM ± 0.5 (n=5), respectively. BCATc Inhibitor 2 decreased calcium influx in neuronal cultures with an IC50 of 4.8 ± 1.2 μM (n=4) .(In Vivo):BCATc Inhibitor 2 blocked calcium influx into neuronal cells following inhibition of glutamate uptake, and demonstrated neuroprotective efficacy in vivo. In Lewis rats, after treatment with 30 mg/kg BCATc Inhibitor 2 (subcutaneous injection), the peak plasma concentration (Cmax) reached 8.28 μg/ml at 0.5 h (tmax). The mean plasma exposure (AUC) value was 19.9 μg h/ml, and the mean terminal half-life ranged from 12 to 15 h, indicating favorable PK parameters of BCATc Inhibitor 2. Daily administration of the mitochondrial neurotoxin, 3-nitroproprionic acid (3-NP) produced striatal lesions and led to motor deficits. Administration of BCATc Inhibitor 2 for 9 days almost completely reversed the effects of 3-NP .
-
体外实验——
-
体内实验——
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体——
-
研究领域——
-
适应症——
化学信息
-
CAS Number406191-34-2
-
分子量418.77
-
分子式C16H10ClF3N2O4S
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 250 mg/mL (596.99 mM)
-
SMILESFC(F)(F)c1ccccc1S(=O)(=O)NNC(=O)c1cc2cc(Cl)ccc2o1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Yingjun Zhang, et al. Sulfonamide derivatives and pharmaceutical applications thereof. EP3134392B1
产品手册




关联产品
-
(S)-3-AMino-2-Methyl...
(S)-3-氨基-2-甲基丙酸-HCl 是一种化合物。
-
Creatine phosphate d...
磷酸肌酸二钠盐四水合物是肌酸激酶测定的底物。
-
Vitamin K1
叶绿醌家族,包含 2-甲基-1,4-萘醌环和类异戊二烯侧链。